NIPER question paper 2009

NIPER Question
1. Which is cytotoxic from following marine? (bryostatin)
2. To avoid crystallization of syrup which substance is added? (polyhydric alcohols)
3. Particle size of fluid energy mill is? (1-30micrometer)
4. Use of Gallic acid? (Antioxidant)
5. HLB of o/w emulsion. (3-8)
6. Range of Visible light? (400-800nm options were in micro so read questions carefully
before attaining )
7. Source of IR (Nerst glower)
8. Hydrogen bonding determined by which method? (Raman)
9. Most intense peak in MASS spectra? (Base peak)
10. How to determine non-UV active structure? (derivatization)
11. Energy comparison of UV, IR n NMR. Means put them in ascending order of their energies.
(NMR least<ir
12. Reference standard used in NMR? (TMS)
13. In IR calibration which substance is used? (Air)
14. What does RS means in IP? (Reference standard)
15. Sparingly soluble? (30 to 100 parts)
16. Cough is S/E of? (captopril)
17. Capsule '000' size capacity?
18. Green bones are made up of which type of gelatin? (type B)
19. Vehicle used in SGC?
20. Which property not related to polymorphism? (chemical assay)
21. Ostwald ripening is related with? (suspension)
22. Osmotic pressure of blood is?
23. Duration of nasal delivery
24. Duration of mucoadhesive delivery
25. Largest cotton producing country
26. Free trade port in India? (Kandla)
27. Amoebiasis is caused by? (E.histolytica)
28. In clock 12'o clock is north east then at 1:30pm what would be direction? (East)
29. In monosubstituted cyclohexane which structure will be stable?
30. Stereochemistry of Alanine
31. Linkage in amylase
32. Teratogenic vitamin? (A)
33. In cyclic carbohydrates stereochemistry is known as? (anomer)
34. Propranolol is contraindicated in? (Asthma)
35. Highest first pass metabolism of following?
a. propranolol (ans) b. digoxin c. Phenobarbital d. phenytoin
36. Which of this is cardiotoxic (Adriamycin)
37. M/A of paclitaxol is?
38. Therapeutic index denotes (Margin of safety)
39. Selective ï ¡ 1 blocker is? (Prazosin)
40. Activity of receptor (drug selectivity and selective antagonist action of drug)
41. Receptors are made up of? (protein)
42. Cytokinins are?
43. Morphine act through ï receptor.
44. Nicotinic receptor work through which messenger system?
45. Example of Neurodegenerative disorder. (Alzheimer's Disease)
46. Action of Ach? (Hastens G.I. emptying)
47. Name of Indian Ginseng? (Withania Somnifera)
48. Father of Chemotherapy? (Paul Ehrlich)
49. Out of following which is not containing bacteria?
a. Soil b. Ice c. Dust d. Blood (ans) (blood is sterile unless infected)
50. Drug approved by US FDA for alopecia? (Minoxidil)
51. Drug interaction is hazardous of following? (terfinadin + erythromycin)
52. Which of following cause cardiac arrhythmia? (terfinadin)
53. ï ¢2 selective(salbutamol)
54. Cerebral Malaria (quinine)
55. Which malaria is deadly? (P. falciperum)
56. Use of Primaquine is? (choloroquine resistant P. falciperum)
57. Tamoxifen used in breast cancer act as? (estrogen antagonist)
58. Metallic elements detected by? (AAS)
59. Enthalpy is measure of?
60. Luminescence, fluorescence and phosphorescence is a type of? (Emission spectroscopy)
61. Rate Kinetic deals with? (order, molecularity and conc of reactant)
62. In exothermic process increase in temp indicate what?
a. Reactant is more b. product yield is more(ans) c. Rxn stopped d. equilibrium
63. Cough syrup mostly contains which alkaloid? (Codeine)
64. Terpenoid are obtained from which biosynthetic pathway?
65. In diosgenin which ring is present?
66. In triterpenoid how many isoprene units are present? (6)
67. In dipeptide bond how many amino acids are present? (3)
68. Which of following contain chromosome or DNA?
a. mitochondria (ans) b. ER c. Golgibody d. cytoplasm
69. t-RNA function
70. Inhibition of mammalian gene expression is at the level of?
71. IPEC deals with?
a. Excepient (ans) b. US FDA c. GMP d. GLP (International Pharmaceutical Excipient Council)
72. ABC analysis deals with? (Inventory control)
73. Phase- IV deals with?
74. IND is for? (filling of NCE New Chemical Entity now changed to NME New Molecule Entity as biomolecules are not considered as chemical)
75. Minimum velocity required for laminar air flow unit? (100)
76. Cardiac Ca++ channel blocker? (nifedipine)
77. Ca++ channel use which type of messenger system?
78. Fill in the gap: stu_ _ st _ _ ws _ _ vw (vwuvtu)
79. Which of following is endothermic?
a. Adsorption b. crystallization c. vaporization d. all
80. Betaine structure (Refer Wittig reaction)
81. Structure of nifedipine.
82. Stereochemistry in biphenyl
83. How to determine unsaturation? (bromination,hydrogenation,ozonolysis)
84. NMR signal obtained in 1,4- dioxane (1 peak)
85. Reaction occurring in ethane? (E1 )
86. Tomato red pigment is due to? (Lycopene)
87. Insulin act on which cells? (Beta)
88. PG released by (COX-II)
89. Aspirin is? (Irreversible COX inhibitor)
90. Phenytoin used in? Digitalis induced arrhythmia)
91. Serotonin is neurotransmitter
92. Alcohol dehydrogenase converts (ethanol to acetaldehyde)
93. Major product obtained from purine metabolism is? (Uric acid)
94. Saffron cultivated in (Jammu n Kashmir)
95. Benzyl alcohol 1% is used as Preservative
96. Cetyl ether of Polyethylene glycon is known as? (Cetomacrogol)
97. Detector used in spectrophotometer? (Photo multiplier tube)
98. Living organisms are detected by? (Dark field microscopy)
99. Which of following is not static? (Flash dryer)
100. Rifampicin used not only in TB but also in? (Leprosy)
---------------------------
01. Immunoglobulin is? (2 light, 2 heavy, disulfide)
02. Which of following not causing enzyme induction? (Sulfonamide)
03. Detector used in IR? (Thermocouple)
04. Function of microvilli is? (Increase surface area)
05. pH of 0.005M HCL?
06. pH of pKa 5.4 is?
07. IR range of CO (acid chloride)
08. Neostigmin does not cross BBB? (Polar)
09. Drugs which cross BBB are? (lipophilic drugs)
10. Which is most commonly used HPLC? (Reverse Phase)
11. Phenolphthalein is? (Acid base indicator)
12. Drug assayed by acid-base back titration? (Aspirin)
13. Which of following is titrated using strong base? (Refer IP for titrations, this can be
considered as important)
14. Amiloride and Spiranolactone differs in?
15. Statin mechanism? (Reduce cholesterol)
16. Which of following is not related with enalapril (It is not an AT1 antagonist)
17. Equation of Angle of Repose.
18. Character of liposome is?
19. Eye drops and parentral differ in?
20. Colchicines is used in Gout.
21. Omeprazole act by?
22. Muscarinic antagonist used in ulcer.
23. Most commonly used in PD? (L-dopa)
24. Dopamine agonist used in PD. (Bromocryptine)
25. Which of this is not acting on nuclear receptor? (Amino acid trypsin)
26. Nucleus present in coumarin.
27. Which of following is used in vascular disorder? (Ginko biloba)
28. Podophyllotoxin is? (Lignan)
29. Bacterial cell wall consists of? (Heteropolysaccharide)
30. In indole biosynthesis which AA is used? (Typtophan)
31. Sugar in protein preparation act as? (cryoprotective)
32. Non aq. Binder
33. Flow of genetic information (DNA to RNA to Protein)
34. Iodine Value
35. SDS-PAGE is used for? (Protein)
36. Yield calculation of synthesis.
37. Thermal assay (DSC)
38. Auxochrome function.
39. Supreme commander? (President)
40. Vant Hoff equation
41. Nitrites? (Vasodilation)
42. CH3 F (deshielded so downfield)
43. Expiry date determined by use of drug along with container.
44. Which is most permeable to moisture? (Polyethylene)
45. Accelerated stability study is done at what temp n RH?
46. Dose required for intradermal delivery.
47. Aim of welfare state.
48. Solubilsation is based on (Stereochemistry)
49. Circular diachronism spectroscopy is used for? (Optically active compound)
50. Simple and compound interest calculation.
51. Digitalis acts by Na+ / K+ ATPase Pump
52. Syphilis is caused by?
53. Acetazolamide? (Carbonic anhydrase inhibitor)
54. Unit of delta(ppm)
56. HIV is caused by? (Virus)
Apart from this is contains many mathematical calculations, synonyms, antonyms and acronyms.

(And same paper is their for MBA and MS)

Note: In form they provide one option for sponsor seat do tick that option it do not require any industrial recommendation but it is one sort of payment seat. If you don't tick that option you will not be eligible for taking admission in payment seat.

Few useful acronyms.
1. CPCSEA- Committee for Purpose of Control and Supervision of Experimental Animals.
2. IAEC- Institutional Animal Ethics Committee
3. BEA-Breeding for Experimental Animals
4. SDS-PAGESodium Dodecyl Sulfate- Polyacrylamide Gel Electrophoresis
5. NME- New Molecular Entity
6. NCE- New Chemical Entity
7. GRAS- Generally Accepted As Safe
8. ANDA- Abbrevated New Drug Application (Generic filling)
9. IIG- Inactive Ingredient Guide

Note: Answers given in bracket is best of the options given. It might not be the most appropriate answer for that question. And don't rely on answer completely we have wrote what we were able to remember so please do check textbooks.

NIPER JEE 2005

flow injection system in HPLC?
fingerpoint region in IR?
trance stilbens?
alfa and beta d-glucose structure?
most suitable diluent for controlled releae/
solvents in reverse phase chromatography?
RNA and DNA str?
reverse transcriptase enzyme?
chloroquin used in ..?
artemisin ?
asparginase?
kaalfischer titration?
alkaloid which is not therapeutical active?
configuration of ephedrine/
endogenous anticoagulant?
Sulfonylureas?
what happend in type 2 daibetes?
afficacy and affinity?
What is nitric oxide?
type of Ca++ present in heart?
Action of dopimine?
antagonist of levodopa?
First law of thermodinamicss/
cubic nature of NACl?
mechanism of adaptogen/
NMR
UV calculation
mass calculation of fragments?
rimer-timen reaction.
Find distereomers?
route of administration?
gingival hyperplasia is a side effect of?
isoprene unit of FPP?
analytical technique of noble druges?
stop codon?</ir

effect of cancer chemotherapy on reproduction and sexuality

Reproduction and sexuality

Reproductive and sexual problems can occur after you receive chemotherapy. Which, if any, problems develop depends on your age when you are treated, the dose and duration of the chemotherapy, and which chemotherapy drugs are given.

Sexual changes men may experience

Most men on chemotherapy still have normal erections. A few, however, may develop problems. Erections and sexual desire often decrease just after a course of chemotherapy, but usually recover in a week or two. A few chemotherapy drugs, for example cisplatin or vincristine, can permanently damage parts of the nervous system. Although it is not yet proven, these drugs may interfere with the nerves that control erection.

Chemotherapy can sometimes affect sexual desire and erections by decreasing the amount of testosterone produced. Some of the drugs used to prevent nausea during chemotherapy can also upset a man's hormone balance, but hormone levels should return to normal after treatments have ended.

Many chemotherapy drugs can affect sperm and the parts of the body that produce them. Some of these effects may be permanent. Freezing sperm before chemotherapy begins is one option for men who wish to father children later in life. (If you would like to read more about this, see our document called Fertility and Cancer: What Are My Options?)

Although it is sometimes possible to father children during chemotherapy, the toxicity of some drugs may cause birth defects. Because of this, it is suggested that all men getting chemotherapy take precautions and use a reliable type of birth control if they are sexually active.

Chemotherapy may suppress your immune system. If you have had genital herpes or genital wart infections in the past, you may have flare-ups during chemotherapy.

Chemotherapy is often given through an IV tube into the bloodstream. However, new ways have been developed to get drugs directly to a tumor. For cancer of the bladder, for example, chemotherapy is placed right into the bladder through a catheter in the urethra. Such a treatment has only a minor effect on a man's sex life. You may notice some pain if you have sex too soon after the treatment. This is because the bladder and urethra are still irritated.

For more information, please see our document Sexuality for the Man With Cancer.

Sexual changes women may experience

Many chemotherapy drugs can either temporarily or permanently damage a woman's ovaries, reducing their output of hormones. This affects a woman's fertility and libido (sex drive). Ovarian function is less likely to return in women over age 30, so they are more likely to go into menopause. (If you would like to read more about preserving fertility, see our document called Fertility and Cancer: What Are My Options?) Symptoms of early menopause include hot flashes, vaginal dryness and tightness during intercourse, and irregular or no menstrual periods. As the lining of the vagina thins, light spotting of blood after intercourse becomes common.

Even though menstrual cycles may be disrupted or stopped with chemotherapy, it may still be possible to get pregnant at this time. The toxicity of some chemotherapy drugs may cause birth defects. Because of this, women getting chemotherapy should take precautions and use a reliable type of birth control if they are sexually active.

Some chemotherapy drugs irritate all mucous membranes in the body. This includes the lining of the vagina, which often becomes dry and inflamed (a condition called vaginitis).

Vaginal infections are common during chemotherapy, particularly in women taking steroids or powerful antibiotics used to prevent bacterial infections. Yeast cells are a natural part of the vagina's cleansing system. If too many grow, however, you may notice itching inside your vagina, a whitish discharge that often looks like cottage cheese, or a burning sensation during intercourse. Yeast infections can sometimes be prevented by not wearing pantyhose, nylon panties, or tight pants. Loose clothing and cotton panties allow better air circulation. Your doctor may also recommend a vaginal cream or suppository to reduce yeast cells or other organisms that grow in the vagina. Most of these medicines can be bought without a prescription, although there are treatments that can be taken by mouth that must be prescribed by a doctor. It is very important to have vaginal infections treated if you are getting chemotherapy. Your body's immune system is not as strong because of the treatment, and any infection may become a more serious problem if it is not dealt with as early as possible.

If you have had genital herpes or genital wart infections in the past, you may have flare-ups during chemotherapy. This is because the chemotherapy suppresses your immune system.

Chemotherapy is often given through an IV tube into the bloodstream. However, new ways have been developed to bring drugs directly to a tumor. For cancer of the bladder, for example, chemotherapy is placed right into the bladder through a catheter in the urethra. Such a treatment usually has only a minor effect on a woman's sex life. You may notice some pain if you have sex too soon after the treatment. This is because the bladder and urethra are still irritated